Treatment of Asthma by Chronotherapeutic Drug Delivery System using Salbutamol Sulphate

D. Manasa*, C. S. Parameswari, B.V. Ramana, G. Nagarajan
Dr. K.V. Subba Reddy Institute of Pharmacy, Kunrool, Andhra Pradesh, India

A B S T R A C T
The objective of the present investigation was to formulate and evaluate Salbutamol sulphate by chronotherapeutic drug delivery system. In chronopharmacotherapy (timed drug therapy) drug administration is synchronized with biological rhythms to produce maximal therapeutic effect and minimum harm for the patient. Salbutamol is a short-acting, selective beta2-adrenergic receptor agonist used in the treatment of asthma and COPD. Seven formulations of extended release tablets were prepared using 7 mm concave punch with single station tablet compression machine with polymer such as HPMC K100, HPMC K15M, sodium CMC, methyl carboxy cellulose and magnesium stearate in different ratios. The evaluation results revealed that all formulations comply with the specification of official pharmacopoeias and/or standard reference with respect to general appearance, content uniformity, hardness, friability and dissolution.  Out of all the formulation developed, formulation F2 containing of HPMCK15 showed better Pulstile drug release of Salbutamol sulphate. Formulated tablets showed satisfactory results for various Post compression evaluation parameters like: tablet thickness, hardness, weight variation, floating lag time, total floating time, content uniformity and in vitro drug release.
Keywords: Salbutamol sulphate, Chronopharmacotherapy, HPMC K100, Extended release, Formulation, Pulsatile drug release