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S. Cosmas, O.A Durojaye*, R. O Asomadu, I. N Amorha, O. I Diyoke, G. A Osegbo Department of Biochemistry, University of Nigeria, Nsukka A B S T R A C T Trypanosoma brucei is a unicellular parasite causing African sleeping sickness in cattle and humans. Infection occurs when a vector tsetse fly bites a mammalian host. The fly injects the ... Read More »
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Tag Archives: molecular docking
Novel 4-Thiazolidinone derivatives act as potential Voltage Sensitive Sodium Channel Inhibitors
Soma Acharjee1, Asish Bhaumik*2, V. Shwetha3, Sk. Nagulmeera2, N. Santhosh Kumar2, M. Swapna2 1Department of Pharmaceutical Chemistry, Regional Institute of Pharmaceutical Science and Technology, Agartala, Tripura, India-799005. 2Department of Pharmaceutical Chemistry, Teja College of Pharmacy, Kodad, Nalgonda-508206, Telangana, India. 3Department of Pharmaceutical Analysis, Pratishta Institute of Pharmaceutical Sciences, Durajpally, Chivemla, Nalgonda-508214, Telangana State, India. A B S T R A C T The ... Read More »
SAR Study, Molecular Property and In Silico study of Novel Tetrahydroquinolines bearing Trifluoromethyl Group for Anticancer, Antimalarial, Anti HIV Activities
PS Pradeep, NM Jagadeesh, HC Kiran Kumar, KM Mahadevan* Department of Post Graduate Studies and Research in Chemistry, School of Chemical Sciences, Kuvempu University, P. G. Centre, Kadur, Karnataka-577 548, India. A B S T R A C T A milder and efficient method was described for the synthesis of cis-1-(2-(4-(trifluoromethyl) phenyl)-1, 2, 3, 4-tetrahydroquinolin-4-yl) pyrrolidin-2-ones/azepan-2-ones (3a-d, 4a-d) via imino Diels-Alder ... Read More »
SAR Study, Molecular Property and In Silico study of Novel Tetrahydroquinolines bearing Trifluoromethyl Group for Anticancer, Antimalarial, Anti HIV Activities
PS Pradeep, NM Jagadeesh, HC Kiran Kumar, KM Mahadevan* Department of Post Graduate Studies and Research in Chemistry, School of Chemical Sciences, Kuvempu University, P. G. Centre, Kadur, Karnataka-577 548, India. A B S T R A C T A milder and efficient method was described for the synthesis of cis-1-(2-(4-(trifluoromethyl) phenyl)-1, 2, 3, 4-tetrahydroquinolin-4-yl) pyrrolidin-2-ones/azepan-2-ones (3a-d, 4a-d) via imino Diels-Alder ... Read More »
Molecular docking study on myricetin derivates as the inhibitors of Glucosyl transferase SI, a virulence factor of Streptococcus mutans in the causation of dental caries
ABOUT AUTHOR Kannan I*, Roshini.G, Sambandam Cecilia, Jayalakshmi M, Premavathy RK, Shantha S Department of Microbiology, Tagore Dental College and Hospital, Rathinamangalam, Chennai– 600127, India Abstract Dental caries is one of the most prevalent infectious diseases in the world. Streptococcus mutans is regarded as a primary microbial agent in the pathogenesis of dental caries. The role of S. mutans in ... Read More »
An insilico molecular docking study of myricetin derivatives as inhibitors of SspB, a virulence factor of oral pathogen Streptococcus gordonii.
ABOUT AUTHOR Kannan I*, Priyanka K, Sambandam Cecilia, Jayalakshmi M, Premavathy RK, Shantha S Department of Microbiology, Tagore Dental College and Hospital, Rathinamangalam, Chennai–600127, India *E-mail: kannan_iyan@hotmail.com Abstract Streptococcus gordonii is a commensal bacterium which colonizes different sites of human oral cavity. It is strongly believed that S. gordonii plays an important role in the development of bacterial communities associated ... Read More »
An Insilico design of Inhibitors of GspB, a virulence factor of Streptococcus gordonii in the causation of infective Endocarditis
About author Kannan I*, Iswarya K, Sambandam Cecilia, Jayalakshmi M, Premavathy RK, Shantha S Department of Microbiology, Tagore Dental College and Hospital, Rathinamangalam, Chennai – 600 127, India E-mail: kannan_iyan@hotmail.com Abstract Infective endocarditis is an infection of the endocardial surface of the heart. The disease may be fatal if untreated as the disease may lead to intractable congestive heart failure ... Read More »
