Synthesis of Thiazole Derivatives—A Review

Gobala Krishnan P*¹, Gnana Prakash K², Chandra Sekhar K.B^3
1Department of Pharmaceutical Chemistry, Vagdevi college of Pharmacy and Research Centre, Brahmadevam, Muthukur, Nellore, Andhra Pradesh, India.
²Department of Pharmaceutics, P Rami Reddy Memorial college of Pharmacy, YSR District, A. P, India.
³Department of Pharmaceutical Chemistry, JNTUA–Oil Technological & Pharmaceutical Research Institute, Anantapuramu, Andhra Pradesh, India.

A B S T R A C T
A number of heterocyclic derivatives containing nitrogen have been used as versatile scaffolds in drug development. Thiazole is one of the heterocyclic compounds with remarkable pharmacological activities. Thiazole derivatives were found to possess the biological activities like anti-convulsant, anti-microbial, anti-inflammatory, anti-cancer, anti-HIV, anti-diabetic, anti-alzheimer, anti-hypertensive, anthelmintic and anti-oxidant activities. Due to its biological activities it has great pharmaceutical importance; hence, synthesis of this compound is of considerable interest. This review mainly focuses on the research work reported in the scientific literature on different synthetic procedures of Thiazole compounds.
Keywords: Synthesis, substituted thiazole, Thiazole derivatives.