El Houssine Mabrouk and Abdelilah El Hallaoui
Laboratory of Organic Chemistry, Faculty of Sciences Dhar El Mahraz, University Sidi Mohamed Ben Abdellah, B.P. 1796, Fez, Morocco
A B S T R A C T
A simple synthetic approach to racemic methyl 2-benzamido-2-(N-benzyl N-ethylamino) acetate in high yield is reported. This synthesis involves the N-alkylation reaction between methyl α-bromo glycinate or methyl α-azido glycinate N-benzoylated and N-benzyl-N-ethylamine in different solvents in the presence of various bases. The structure of this product was established on the basis of NMR spectroscopy (1H, 13C), and MS data.
Keywords: Amine; N-alkylation; α-Amino acids; Methyl α-azido glycinate, methyl α-bromo glycinate.