Synthesis of Some Novel Benzimidazole Derivatives & Evaluation of Their Antibacterial Activity

Jayakumar.A*, Ramesh Dhani, Sindhu.P, Ayesha.K, Keerthi. V, Rajeswari.P, Sukanya.P, Vijayadurga.P,
Department of Pharmaceutical Chemistry, Ratnam Institute of Pharmacy, Pidathapolur (V&P), Muthukur (M), SPSR Nellore District-524 346

ABSTRACT
Benzimidazoles are heterocyclic compounds in which benzene is fused with five membered ring containing two hetero atoms. Both hetero atoms are nitrogen (N), which are present at non-adjacent position. It has broad spectrum of activity which are  anti-ulcer, antitumor, antiviral and antibacterial agent and many more due to these biological effects it has drawn more interest in synthesis and derivatization of benzimidazole derivatives by modifying the antimicrobial activity. The benzimidazole moiety is a core structure we have focussed on the antibacterial and antimicrobial activity of the newly synthesized derivatives  by suitable methods.
Key words: Benzimidazole, hetero atom, anti-bacterial, anti-microbial