Synthesis of N-Substituted Tetrahydrocarbazoles and Anticonvuslant Activity of Synthesised Compounds

Subrahmanyam Lanka^{* 1}, Vaikuntarao Lakinani¹, Eswara Rao Bammidi¹, Siva Rama Rao Kakani^2
1Department of Chemistry, GITAM Institute of Science, GITAM University, Visakhapatnam, India
²Noida Internatioanl University, NOIDA, U.P

A B S T R A C T
Thrust in the preparation of new heterocyclic molecules is increasing due to their proven significant biological activities. The paramount importance of heterocycles such as indoles and their derivatives in natural product chemistry and pharmacology constantly drives the search for the new procedures for their construction and also for the preparation of variety of their derivatives to exploit their useful biological activities. A substituted tetrahydrocarbazole had been synthesized by reacting cyclohexanones with substituted hydrazine hydrochlorides in the presence of glacial acetic acid to produce N-(1,2,3,4-tetrahydrocarbazole) which later used to synthesize compounds with different heterocyclic new rings containing, sulfur and nitrogen in structures i.e., substituted-N-(1,2,3,4-tetrahydrocarbazole ) which were  characterized by IR, ¹H and ¹³C NMR spectral studies and these structures were investigated for analgesic and anti inflammatory activity.
Keywords: Cyclisation, substituted phenyl hydrazine, cyclohexanone, Tetrahydrocarbazole