Synthesis, Characterization of New Mercaptobenzoxazole Fused Mannich Bases for Anti-inflammatory and Antibacterial Activity

Kalyani¹ G*, Bethi Srinivas²,   Sastry³ K.V, Vijaya Kuchana¹ K
¹Department of Pharmaceutical Chemistry, TKR College of Pharmacy, Hyderabad
²Department of Pharmaceutical Chemistry, Talla Padmavathi college of pharmacy, Warangal.
³Department of Pharmaceutics, Alliance institute of pharmaceutical sciences, Hyderabad.

A B S T R A C T
Mercaptobenzoxazole is a heteroaromatic chemical compound from the class of Benzoxazoles. A new series of Mercaptobenzoxazole compounds were synthesized from 2-Amino phenol, Carbon disulfide and in presence of ethanoic KOH when undergo mannich reaction i.e. reacted with secondary amines and furfuraldehyde in presence of ethanol eliminates the water molecule and gives mannich bases containing 2-Mercaptobenzoxazole. All the synthesized compounds were characterized by IR, ¹H NMR and MASS Spectroscopic methods and the synthesized compounds reaction i.e. reacted with secondary amines and furfuraldehyde in presence of ethanol eliminates the water molecule and gives mannich bases containing 2- Mercaptobenzoxazole. All the synthesized compounds were characterized by IR,¹H NMR and MASS Spectroscopic methods and the synthesized compounds were evaluated for Anti-bacterial activity against gram negative E. coli and anti-inflammatory activity.
Keywords: Mercaptobenzoxazole, Mannich Base, Furfuraldehyde, IR, ¹H NMR, Mass Spectroscopy, Antibacterial activity, Anti-inflammatory activity