Synthesis and Screening of (E)-1-(4-(2(((Phenylamino) Methyl) amino) acetyl) phenyl)-4-(2-phenylhydrazono)-3-(Trichloromethyl)-1H-pyrazol-5(4H)-one

G.S.S. Anjaneya Vasavi, M. Uma Maheshwar Rao, S. Sreenivasulu*, M. Venu Gopal  
Department of Chemistry, R.G.M. College of Engineering Technology (Autonomous) Nandyala

A B S T R A C T
Synthesis of (E)-1-(4-(2-(((phenylamino) methyl) amino) acetyl) phenyl)-4-(2phenyl hydrazono)-3-(trichloromethyl)-1H-pyrazol-5(4H)-onewasachievedbyreactionofE-2-(4-(5-o4(2phenylhydrazono)-3-(trichloromethyl acetic acid (2)) in presence of DMF, aq NaNO_3, isobutyl formamide afforded corresponding compound (3) which was subjected to mannich reaction with cyclic secondary amines such as piperidine or morphline or N-methyl piparazinein presence of formaldehyde in DMF to yield corresponding mannichbase (E)(4(2(((phenylamino)methyl)amino)acetyl)phenyl)-4-(2phenylhydrazono)-3-(trichloromethyl)-1H-pyrazol-5 (4H)-one (4) in excellent yield. The structure of these newly synthesized compounds were characterized by H¹-NMR, C¹³-NMR, Mass and IR elemental analysis
Keywords: Pyrozolone, Mannich bases, β-lactum, urea.