Synthesis and Screening of Anti-inflammatory activity of Coumarins bearing oxy acetic acid moiety

S. A. Tamboli¹*, Dr. B. Y. Mane^2
1Department of Pharmaceutical Chemistry, Padamshree Dr. Vittalrrao Vikhe Patil Foundation’s College of Pharmacy, Ahmednagar, Maharashtra, India-414 111.
²Asst. prof., Department of Pharmaceutical Chemistry and PG studies, Padamshree Dr. Vittalrrao Vikhe Patil Foundation’s College of Pharmacy, Ahmednagar, Maharashtra, India-414 111.

A B S T R A C T
Coumarins and its derivatives are considered as the most active classes of heterocycles, which possess a broad spectrum of biological activity. They have been proven to be active as antibacterial, antifungal, anti-inflammatory, anti-depressant, anti-HIV and antitumor agents. Moreover, Coumarin and its related derivatives have been used as inhibitors of lipoxygenase (LOX) and cyclooxygenase (COX) pathways of arachidonic acid metabolism. In the present study, we have evaluated the anti-inflammatory and antimicrobial activity of some newly synthesized Coumarin derivatives. In search for new anti-inflammatory agents with improved safety profiles, some new 7-hydroxycoumarin derivatives bearing functionalized aryl oxy acetic acid moieties were synthesized. This prompted us to synthesize a series of novel Coumarin derivatives with oxy acetic acid moiety and evaluate their anti-inflammatory activity. The structures of the final newly synthesized compounds were confirmed from IR, ¹HNMR and Mass spectra. Among the newly synthesized compounds,3e, 3f, 3g, 3h, 3i and 3j showed maximum anti-inflammatory activity in comparison to standard drug Ibuprofen.
Keywords: 7-hydroxy-4-methyl Coumarin, Oxy acetic acid moiety, Anti-inflammatory activity, Rat paw edema model, IR, NMR.