Synthesis and Biological Evaluation of Coumarin -3-Substituted-Oxadiazole Derivatives

Megha P*^a, D. Ramesh^a, T. Yunus Pasha^a, B. Ramesh^a, Rashmi N. G^b, K. Byrappa^b, Namratha Keerthiraj^b, Dr. Chandra Nayak S^b
aDepartment of Pharmaceutical Chemistry, Sri Adichunchanagiri College of Pharmacy, Adichunchanagiri University, B.G Nagar-571448, Nagamangala Taluk, Mandya, Karnataka.
^bCo-ordinator Vijnan Bhavan Manasagangothri University of Mysore.

ABSTRACT
Coumarin is an aromatic organic chemical compound it is described as a benzene molecule with two adjacent hydrogen atoms replaced by a lactone like chain –o- forming a second six-membered heterocycle that shares two carbons with the benzene ring and an important group of heterocyclic compounds that are known for their properties such as an antibacterial, anticoagulant and anticancer disease etc. Oxadiazole moiety in association with various heterocyclic rings form 1,3,4-oxadiazoles which are important heterocyclic compounds that are synthetically useful and biologically active. They show significant growth inhibition against S. aureus and E.coli species in vitro. The current study is aimed at synthesis and study of antimicrobial activity of compounds incorporating coumarin and 1,3,4- oxadiazoles. All the compounds have been characterized by IR, Mass and ¹H-NMR Spectroscopy.
Keywords: Coumarin, Antibacterial activity, 1,3,4-oxadiazole.