Symbiosis of toll like Receptors and Dendritic cells in vaccine development

Amit Gupta*, Pallavi Khamkar and Sushama R Chaphalkar
Vidya Pratishthan’s School of Biotechnology (VSBT), Vidyanagari Baramati-413133, Pune, India.

ABSTRACT
The activation of the adaptive immune system is generally dependent on antigen presenting cells i.e. dendritic cells and macrophages. One of members which are already present on dendritic cells i.e. Toll-like receptor is key regulators of both innate and adaptive immune responses. Accordingly, recent evidence from human studies and experimental animal models studies which implicates that toll like receptors played an important role in vaccine development. However, fundamental questions remain unanswered concerning the actual role of toll like receptors in dendritic cell. In this review, we discuss the proposed roles of toll like receptors in dendritic cells and correlates with vaccine development.
Keywords: Toll like receptor, immune, vaccine, dendritic cells, macrophages