Simple Validated UV method for Cinacalcetin Bulk and Its Tablets Dosage Form

Anilkumar P, Mohammed Ishaq B, Hindustan Abdul Ahad, Kalyani K, Khadeera C
Balaji College of Pharmacy, Rudrampeta bypass, Ananthapuramu, AP, India

A B S T R A C T
Cinacalcet is prescribed to Hyperparathyroidism patients. The present research work is to develop and validate Cinacalcet by UV spectrometric method. Simple, accurate, precise and cost efficient spectrophotometric method has been developed for the estimation of Cinacalcetin bulk and its tablets dosage form. The optimum condition for the analysis of the drug was established. The maximum wavelength (λ_max) was found to be 271.74nm in Methanol. The mean percentage recovery of Cinacalcet was found to be in range of 99.40-101.64%. Beers law was obeyed in the concentration range of 10-200μg/ml.  Calibration curve shows a linear relationship between the absorbance and concentration. The line equation y = 0.0109x+0.123 with R² = 0.9982 was obtained. Validation was performed as ICH guidelines for linearity, accuracy, precision, LOD & LOQ. The proposed method may be suitable for analysis of Cinacalcet in bulk and tablets formulation for routine quality control purposes.
Keywords: Cinacalcet tablets, UV spectrophotometric, beers law