Pulsatile Drug Delivery System: An Approach for Control Drug Delivery

B. Krishna Moorthy*, D. Vijay kumar, K. Madhu, A. Aruna, M. Divya
Jagans College of Phramacy, Jangala Kandriga, Muthukur, SPSR Nellore, A.P. 524346

A B S T R A C T
Pulsatile drug delivery systems (PDDS) are gaining importance in the field of pharmaceutical technology as these systems deliver the right dose at specific time at a specific site. These systems are designed according to the circadian rhythm of the body. The principle rationale for the use of pulsatile release is for the drugs where a constant drug release, i.e., a zero-order release is not desired. The release of the drug as a pulse after a lag time has to be designed in such a way that a complete and rapid drug release follows the lag time. These systems are beneficial for the drugs having chronopharmacological behaviour where night time dosing is required and for the drugs having high first-pass effect and having specific site of absorption in GIT. Some of the disease conditions wherein PDDS are promising include duodenal ulcer, cardiovascular diseases, arthritis, asthma, diabetes, neurological disorder, cancer, hypertension and hypercholesterolemia.
Keywords: Pulsatile drug delivery systems, circadian rhythm, zero-order, lag time and chronopharmacological.