Preparation and Characterization of Paclitaxel Nanoparticle by Precipitation Technique

K. Sunil Kumar¹, C. Nazeer², V. Vanisree³, P. Ramya⁴, R. Latha⁵, C. Sisindra^6
1Associate Professor, Department of Pharmaceutics, Sun Institute of Pharmaceutical Education and Research, Kakupalli, Nellore, Andhra Pradesh, India.
^2,3,4,5,6Sun Institute of Pharmaceutical Education and Research, Kakupalli, Nellore, Andhra Pradesh, India.

A  b  s  t  r a c t
Paclitaxel is a microtubule-stabilizing agent which promotes polymerization of tubululin causing cell death by disrupting the dynamics necessary for cell division. It has neoplastic activity especially against primary epithelial ovarian carcinoma, breast, colon, and non-small cell lung cancers. Paclitaxel is poorly soluble in aqueous solutions but soluble in many organic solvents such as alcohols. It therefore lends itself well to more advanced formulation strategies. In the present investigation, an attempt was made to prepare Paclitaxel Silver Nanoparticle by precipitation technique. In order to stabilize the size of particle, various concentrations of Silver nitrate and Trisodium citrate to be used. Prepared Nanoparticle to be optimized by their encapsulation efficiency, particle size and Release rate. Zeta potential and SEM study also included in the investigation.
Keywords: Paclitaxel, nanoparticles, Zetapotential