In-Vitro Anti Cataract Activity of Adenia Cissampeloides against Glucose -Induced Cataractogenesis

Ashok Reddy D*, Bharghava Bhushan Rao P¹, A.M.S. Sudhakar babu², P. Jyothi³, A. Kishore babu⁴, Padma R⁵, K. Narsu kumari⁶, Sowjanya P⁷
*²³⁴⁵⁶⁷A.M.Reddy Memorial College of Pharmacy, Narasaraopet, 522412, A.P, India
¹V V Institute of Pharmaceutical Sciences, Gudlavalleru A.P, India.

A  B  S  T  R A C T
Cataract is defined as opacity within the clear natural crystalline lens of the eye, which gradually results in vision deterioration. The World Health Organization (WHO) estimated that in 1990, out of the 38 million blind people worldwide, cataract accounted for 41.8% – almost 16 million people. With a projected increase in the geriatric population, WHO has estimated that there will be 54 million blind people aged 60 years or older by the year 2020. Accordingly, cataract surgery will continue to weigh heavily on health care budgets in the developed nations. In the United States, cataract-related expenditure is estimated to be over $3.4 billion annually. In the developing world, the number of new cataract cases supersedes the number of new cataract cases supersedes the rate of surgical removal. In Africa alone, only about 10% of the 5,00,000 new cases of cataract blindness each year are likely to have their sight restored surgically. It is estimated that if onset of cataract could be delayed by 10 years the annual number of cataracts could be delayed by 10 years, the annual number of cataract surgeries performed would be reduced by almost a half. This calls to question the risk factors of this multifactorial disease, which have been a litany of genetic, environmental, socioeconomic, and biochemical factors working in an interlaced fashion. The purpose of this work is tp determine the catratogenesis of plant extract of Adenia Cissampeloides to treat against glucose induced catratogenesis.
Keywords: Cataract, blindness, Adenia Cissampeloides