Pharmacokinetic Drug Interaction of Quetiapine and Pioglitazone in Animal Models

Bhupalam Pradeepkumar ^1*, Y. Padmanabha Reddy ², N. Devanna^3
1Department of Pharmacology, Center for Pharmaceutical Research, Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu-515721, Andhrapardesh, India.
² Principal, Raghavendra Institute of Pharmaceutical Education and Research, Anantapuramu – 515721, A.P, India.
³ Principal, JNTUA College of Engineering, Kalikiri – 515234, Andhra Pardesh, India.

A B S T R A C T
The present study was performed to investigate the effect of quetiapine on the pharmaco dynamics and pharmacokinetics of pioglitazone in rats (normal and diabetic) and rabbits to evaluate the safety and effectiveness of the combination. The blood samples were collected and analyzed for estimation of blood glucose levels by GOD/POD method and serum pioglitazone levels by HPLC method for pharmacokinetic data. The quetiapine alters the pharmacokinetics of pioglitazone and found to enhance the hypoglycaemic effect pioglitazone. Quetiapine appears to produce pharmacokinetic interaction with pioglitazone which might be by competitive antagonisms of its metabolism by inhibiting CYP 3 A4 isozyme and/or by enhancing pioglitazone absorption by inhibiting the P-glycoprotein.
Keywords: Pharmacokinetic drug interaction, Quetiapine, Pioglitazone