Wednesday , 17 July 2024

Development and Validation of RP-HPLC Method for Simultaneous Determination of Donepezil and Memantine in their Tablet Dosage Forms

Srinivas Ganta*, Vidyadhara S Chebrolu Hanumaiah Institute of Pharmaceutical Sciences, Chowdavaram, Guntur-522018, Andhra Pradesh, India. A B S T R A C T A simple, accurate and specific RP-HPLC method has been developed and validated for the simultaneous estimation of Memantine (MEM) HCl and Donepezil (DON) HCl in bulk and pharmaceutical dosage form. Chromatographic separation was achieved on Symmetry C18 ... Read More »

Formulation and Evaluation of Mouth Dissolving Tablets of Betamethasone Using Sublimation Method

K. Swathi*, M. Vijaya Laxmi Department of Pharmaceutics, Teegala Krishna Reddy College Of Pharmacy, Meerpet, Saroornagar, Hyderabad-500 097 A B S T R A C T In the present research work mouth dissolving tablets of betamethasone by direct compression method and using rotary tablet compression machine (mfg by lab press) using 6mm punches. To enhance the solubility of drug by ... Read More »

Analytical Method Development and Validation of Naratriptan in Bulk and Tablet Dosage form using UV Spectrophotometer

R. Chandra Sekhar*, S. Sandeep*, Shaik Faisal Ahmed*, V. Asha Ranjani Marri Laxman Reddy Institute of Pharmacy, JNTU, Hyderabad, Telangana. India. A B S T R A C T Objective: To develop and validate an analytical method for quantitative determination of Naratriptan in bulk and tablet dosage form. Results: The Naratriptan shows absorption maxima at 224.20nm and obeyed Beer’s law ... Read More »

Analytical Method Development and Validation for the Simultaneous Estimation of Metformin and Glibenclamide by RP-HPLC Method in Bulk and Pharmaceutical Dosage Form

Ramanjaneyaulu*, Devika Subrramaniyan.G, Ramesh petchi Rajendran Bomma Institute of Pharmacy, Khammam, Telangana, India A B S T R A C T A reverse phase high performance liquid chromatographic method was developed for the determination of Metformin and Glibenclamide in bulk and Pharmaceutical dosage form. The separation was acheived by using C18 column (4.6×150mm)5µ, flow rate was 1ml/min, mobile phase ratio ... Read More »

Formulation Design and In-vitro Characterization of Topical Drug Delivery System of Clotrimazole Gel

B. Saraswathi*, G. Manasa, Dr. T. Satyanarayana and K. Lalitha Mother Theresa Pharmacy College, Sathupally, Khammam, Telangana, India A B S T R A C T The present research was carried out to develop the topical Clotrimazole ethosomal gels. Even though the TDDS faces the problem of drug permeation because of the rigid stratum corneum, it can be overcome by ... Read More »

Evalaution of Antihyperlipidemic Activity of Tephrosia Purpurea Plant Extracts in Mice

Dr. T. Satyanarayana*, L. Krishnaveni, Alla Nrayanarao, Adapa Satish kumar and G. Sabari Mother Theresa Pharmacy College, Sathupally, Khammam, Telangana, India A B S T R A C T The Present Study is to Evaluate the Anti-Hyperlipidemic Activity of Tephrosia Purpurea Extracts on Triton X-100 induced Hyperlipidemic mice. The mice were divided in to six groups containing four animals in ... Read More »

Formulation and Evaluation of Colon Targeted Drug Delivery System of Ketoprofen using HPMC K4M and Sodium Alginate as Polymeric Carrier

V. Kalvimoorthi*1, M. Purushothaman*2 1Sun Rise University, Alwar, Rajasthan – 301030, India 2Scient Institute of Pharmacy, Ibrahimpatnam, Ranga Reddy (Dt), Hyderabad, Talangana-501 506, India. A B S T R A C T The aim of the present work was to develop and evaluate colon specific sustained release tablet using Ketoprofen, microbially degradable polymeric carrier (HPMC K4M & Sodium Alginate), coating ... Read More »

Anticancer activity of Piperazine Propyl-4-Oxo-3,4-Dihydroquinazoline-2-Carboxylate Derivatives

A. Gopi Reddy1, V. Harinadha Babu1*, Y. Jaya Prakash Rao2 1Department of Pharmaceutical Chemistry, G. Pulla Reddy College of Pharmacy, Hyderabad. 2Department of Chemistry, Telangana University, Nizamabad, Telangana A B S T R A C T In this study, The synthesized piperazine propyl-4-oxo-3,4-dihydroquinazoline-2-carboxylate derivatives were screened for their in vitro anti proliferative activity in these four different human cancer cell ... Read More »

Evaluation of Analgesic Activity and Anti-Epileptic Activity of Ether Leaf Extract of Guggul

K. N. S. Karthik, Konda Ravi Kumar* Department of Pharmaceutical Chemistry, Hindu college of Pharmacy, Amaravathi Road, Guntur. Andhra Pradesh, India. A B S T R A C T Commiphora mukul is a flowering plant in the family Burseraceae. It is a shrubor small tree, attaining maximum height of 4 m, with thin paper y bark and thorny branches. The ... Read More »

Recent Approaches on Zika Virus: A Review

M. Mallikarjuna*, Bathala Anitha, P. Sai Sandeepan, B. Kumar, Ramesh Dhani Ratnam Institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh, India A B S T R A C T Most of the diseases transmitted by the mosquito bite like west Nile, dengue, chicken gunya and yellow fever. These all are the vector-borne diseases transmitted by the arboviruses. Recently the virus which ... Read More »

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