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Md Afsar Alia and Parag S Royb* aAcharya Jagadish Chandra Bose College, 1/1B, A.J.C. Bose Road, Kolkata – 700020. bDepartment of Chemistry, University of North Bengal, Dist. Darjeeling 734 013, India A B S T R A C T A new Schiff base ligand,H3 (pte-tsc) was synthesized by the condensation of 7-acetonyl-xanthopterin [H2(pte)] and thiosemicarbazide [H(tsc)]. The pterin starting material ... Read More »
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Inslico-Prediction of Drug Solubility in Aquous Media by Theoritical Descriptors and QSAR Method
Elham Baher*, Poneh Ebrahimi, and Naser Darzi Naftchali Faculty of science, Department of Chemistry, Golestan University, Gorgan, Iran. A B S T R A C T The most key factor in transition of drugs across the biological membrane is their solubility in water. In this study, a novel theoretical model was proposed for the prediction of drug solubility in the ... Read More »
Synthesis and Evaluation of Some Substituted New Pyrazoline Derivatives of Biological Interest
Amol S Dighe* Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Loni, Maharashtra, India. A B S T R A C T The synthesis, structure and biological activity of Pyrazoline derivatives have long been the focus of research interests in the field of Medicinal Chemistry. A number of Pyrazoline derivatives have been reported to possess interesting biological activities ... Read More »
Development and Validation of a Stability Indicating RP-HPLC Method for the Determination of Piroxicam in Pharmaceutical Dosage Form
A. Chandra Prabha1, M. Sankar2 and A. Chenthilnathan1* 1Department of Pharmaceutical Chemistry, Manonmaniam Sundaranar University, Tirunelveli–627012, Tamil Nadu, India. 2Caplin Point Laboratories Ltd., Gummidipoondi, Chennai–601201, Tamil Nadu, India A B S T R A C T A stability-indicating RP-HPLC was developed and validated for the determination of Piroxicam in bulk and its injection dosage form. The separation was carried out ... Read More »
Assessment of Genotoxic Effect of Atrazine on Poecilia Sphenops Using Micronucleus Assay
S. Vasanth1&2* and P. Subramanian2 1Assistant Professor, Department of Biochemistry, Annai Violet College, Ambattur, Chennai-600053. 2Department of Animal Science, Bharathidasan University, Tiruchirappalli-620024 A B S T R A C T Atrazine is one of the most effective and cheapest herbicides in the world and is consequently used more frequently than any other herbicide. Atrazine is frequently detected in waters, and ... Read More »
Development and Validation of a New RP-HPLC method for the simultaneous estimation of Sulfamethoxazole sodium and Trimethoprim in finished tablet dosage form
K. Satish*1, V. Karthik Varma2, A. Sunil Kumar3, Kranthi Ponugoti4, J. Karthik5 1,2, 3Department of Pharmaceutical Analysis and Quality Assurance, Vikas College of Pharmaceutical Sciences, Rayanigudem, Suryapet-508376, Telangana, India. 4Department of Pharmacology, Malla Reddy College of Pharmacy, Kompally, Hyderabad-500043, India. 5Department of Pharmceutical Chemistry, Madhira Institute of Technology and Sciences, Madhira Nagar, Chilkur, Nalgonda, Kodad-508206, Telangana, India. A B S T ... Read More »
Phytochemical Investigation and Antidepressant Activity of Coccinia Grandis
A. Hima Bindu, M. Navaneetha, K. Prasad, K. Triveni, S. Ramakrishna, B. Nagendra Babu, Naresh Gorantla* Department of Pharmaceutics, Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India. A B S T R A C T In this present work systemic phytochemical investigation of Coccinia grandis work done and it is also evaluated for antidepressant activity by the aqueous extract of ... Read More »
Identification of Steroids in Different Ayurvedic Formulations Available in Local Market
M. Siddalingeswara, G. Kavya, K. Nandini, K. Sumala, Naresh Gorantla* Department of Pharmaceutics, Balaji College of pharmacy, Ananthapuramu, Andhra Pradesh, India. A B S T R A C T Ayurveda, the science of life is an ancient system of medicine sprouted out in India. The basic formulations in Ayurveda are the Herbomineral preparations like Bhasmas, churnas, lehas, asavas, arishtas etc., ... Read More »
Synthesis of Chiral 3-[[(Aryl) methyl] amino]- and 3-[[(Heteroaryl)-methyl]-amino]-quinuclidines with High Biological Activity against Intracellular Trypansoma cruzi Amastigotes
Bruna Fereira de Souza1, Mayara Roncaglia dos Santos1, Renan Pimentel de Souza1, Simon Bernhard Cämmerer1*, Natália Aimée d´Angelo2, Caio Haddad Franco3, Carolina Borsoi Moraes3 Lúcio H. Freitas-Junior3* 1Instituto de Química, Universidade Estadual de Campinas, Rua Monteiro Lobato S/N, Cidade Universitaria Zeferino Vaz, Barão Geraldo, CP 6154, CEP 13083-970, Campinas, São Paulo, Brasil. 2Instituto de Ciências da Saúde – ICS, Universidade ... Read More »
Isolation and characterization of 6-C-β-D xylosyl, 7-O- β-Dglucosylquercetin from Cucurbita maxima (Pumpkin) flowers
M.M. Senthamilselvi1, N. Muruganantham2*, S. Solomon3 1Principal, Government Arts College, Ariyalur, Tamilnadu, India. 2Assistant Professor, Department of chemistry, Roever Engineering College, Perambalur, Tamilnadu, India. 3Department of chemistry, Periyar E.V.R. College (Autonomous), Trichy, Tamilnadu, India. A B S T R A C T In Indian system of medicine, a large number of drugs of either herbal or mineral origin have been ... Read More »
