Tuesday , 16 July 2024

Medicinal Chemistry of Tyrosine Kinase Inhibitor Drug: A Review

Amol S Dighe*1, Sagar D. Magar1, Nachiket S. Dighe2 Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Loni, Maharashtra, India. A B S T R A C T Tyrosine kinases are a part of many cell functions, including cell signaling, growth, and division. These enzymes may be too active or found at high levels in some types of ... Read More »

Antimicrobial Activity of Crude Extract and Carotenoid Pigments from Flowers

Ms. Ancilla Senoretta B. & Dr. V. Judia Harriet Sumathy Postgraduate & Research Department of Biotechnology, Women’s Christian College, Chennai – 600 006. A B S T R A C T All human pharmaceuticals now in use are originally derived from natural sources. According to studies conducted by the World Health Organization (WHO), about 80% of the world’s population relies ... Read More »

Review on Nanosuspensions

Siddeswara*, M. Pradeep Kumar, M. Santhosh Raja, S. Yasmin, Vijay Kumar Vasavi Institute of Pharmaceutical Sciences, Kadapa, Andhra Pradesh, India-516247 A B S T R A C T Solubility is the crucial factor for drug effectiveness, independence of the route of administration. Large proportions of newly discovered drugs are water insoluble, and therefore poorly bioavailable contributing to deserted development effort. These ... Read More »

Review on Stem Cell Therapy

S.P. Likitha Rao*1, Dr. Anil Middah1, Dr. Neeraj Tandan2 1OPJS University, Rajasthan, India 2SARC (Scientific and Applied Research Centre), Meerut, India A B S T R A C T Stem cells have the ability to differentiate into specific cell types. The two defining characteristics of a stem cell are perpetual self-renewal and the ability to differentiate into a specialized adult ... Read More »

A Green Alternative Approach for Synthesis of 2-Substituted Benzothiazoles Catalysed by NBS in Ultra Sonication Method

Dr. P. Thriveni*, K.P.V. Subba Rao,   M. Hari Krishna Department of Chemistry, Vikrama Simhapuri University, Nellore-524003, A.P, India. A B S T R A C T NBS is an efficient, readily available and cheap catalyst for the synthesis of 2-substituted benzothiazole derivatives by condensation of 2-aminothiophenol and aldehydes under sonication conditions by application of green solvents. This protocol is very ... Read More »

Stability indicating RP-HPLC Method Development and Validation for the Simultaneous Estimation of Olmesertan Medoxomil and Chlorthalidone in Pharmaceutical Formulation

Haribaskar*, T. Revathi, Ramesh Dhani Department of Pharmaceutical Analysis, Ratnam Institute of Pharmacy, Pidathapolur, Nellore, Andhra Pradesh, India A B S T R A C T A new method was established for simultaneous estimation of Olmesertan medoxomol and Chlothalidone by RP-HPLC method.  The chromatographic conditions were successfully developed for the separation of Olmesertan medoxomil and Chlorthalidone by using C18, 250 ... Read More »

Simple, Convergent Synthesis and Characterization of benzimidazole derivatives (pyrazole linked pyridine): Micro-wave, Sonication and Conventional methods

Dr. Bommera Sammaiah, M. Venkanna, Dr. R. Madhusudhan Raju* Department of Chemistry, University College of Science, Osmania University, Hyderabad, India. A B S T R A C T The preparation of skeleton is an important in the novel drug development. Herein, the skeleton is developed based on anti-ulcerative drugs. A convergent synthesis, approached to simplify the synthesis and succeeded to ... Read More »

Analytical Method Development and Validation for the Simultaneous Estimation of Atenolol and Nitrendipine by RP-HPLC Method in Bulk and Pharmaceutical Dosage Form

Gobala Krishnan P*, Munisekhar V, Ranjit Singh B. Rathore Department of Pharmaceutical Chemistry, Vagdevi College of Pharmacy & Research Centre, Nellore, A.P, India A B S T R A C T A new method was established for simultaneous estimation of Atenolol and Nitrendipine by RP-HPLC method.  The chromatographic conditions were successfully developed for the separation of Atenolol and Nitrendipine by ... Read More »

Formulation and Evaluation of Nefidipine Nano Suspension

Pradeep Kumar*, M. Santhosh Raja, S. Yasmin, C. Vijay Kumar Vasavi Institute of Pharmaceutical Sciences, Kadapa, Andhra Pradesh, India-516247 A B S T R A C T Polymeric nanoparticles (PNPs) are defined as particulate dispersions or solid particles with size in the range of 10-1000nm.  Nanoparticles can offer significant advantages over the conventional drug delivery in terms of high stability, ... Read More »

Photocatalytic activity of NiO nanoparticles stabilised with Polyethylene Glycol

Parimalaa,b*, J. Santhanalakshmia aDepartment of Physical Chemistry, University of Madras, Chennai-600025, India bAnnai Violet Arts and Science College, Ambattur, Chennai-600053. A B S T R A C T NiO nanoparticles stabilized with polyethylene glycol (PEG) polymer were synthesized and characterized using FESEM, EDAX, XRD, UV and FT–IR techniques. FESEM image shows that the prepared nanoparticles exhibits leaf structure. From XRD ... Read More »

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