One Potsynthesis of Itaconic Acids from Stobbe Condensation Method

Yadav Hanuman Singh*¹, Gadegone Sunita² and Pande Hemant^3
1,3Dr. Ira Nimdeokar Research Center for Chemistry, Hislop College, Nagpur 440001, India
²Department of Chemistry, Kamla Nehru Mahavidyalaya, Nagpur 440009, India

A B S T R A C T
One pot synthesis of acid esters by Stobbe condensation of alkylidene / arylidene succinates and aldehydes or ketones, their subsequent hydrolysis to diacids were reported. The Stobbe condensation of various aromatic aldehydes or ketones with dimethyl succinate gives different types of diacids [2a, (E)-2-(Butan-2-ylidene) succinicacid)], [2b,(Z)-2-Ethylidenene succinic acid], [2c , 2-Methylene succinic acid)], [2d(Z) 2-Hexyledene succinic acid)], [2e ,(Z)-2-(Hexan-3-ylidene ) succinic acid)]through green approach. The improved yields of Itaconic acid were observed by the green approach method as compared with other classical methods employed so far.
Keywords: Green synthesis, Stobbe condensation, aryl aldehydes & ketones, Itaconic acid and their products.