Mucoadhesive Microspheres – A Review

Sandeep Kumar*, Vinod, Rakesh Kumar
Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak – 124001, India

A B S T R A C T
The current article focuses on the principles of mucoadhesive drug delivery systems based on adhesion to biological surfaces. Microspheres constitute a major part of novel drug delivery system because of their small size and other efficient properties. Mucoadheisve microspheres exhibit a prolonged residence time at the site of application or absorption and facilitate an intimate contact with the biological surface and thus contribute to improve and better therapeutic performance of drugs. This paper discussed briefly about the mucoadhesive microspheres, mechanism of mucoadhesion, current status of various methods of preparation i.e. Ionic Gelatin, Simple Emulsification Phase Separation, Emulsion Solvent Evaporation, Co-acervation and Phase Separation, Spray Drying, Hot Melt Microencapsulation, Hydroxyl Appetite Microspheres in Sphere Morphology, Preparation of microspheres by Tripolyphosphate etc. and methods of evaluations i.e. Size, Shape and surface characterization, Swelling index, Encapsulation efficiency, In-vitro wash-off test, In-vitro dissolution studies. Mucoadhesive drug delivery systems is one of the most important novel drug delivery systems with its various advantages and it has a lot of potential in formulating dosage forms for various chronic diseases.
Keywords: Mucoadhesive Microspheres, Mucoadhesion