METHOD DEVELOPMENT AND VALIDATION OF EFAVIRENZ IN BULK AND PHARMACEUTICAL TABLET DOSAGE FORM BY USING UV–VISIBLE SPECTROPHOMETRIC METHOD

ABOUT AUTHOR
Somsubhra Ghosh*, B. Rajni,  S. Vidyadhar, Dr. David Banji
Department of Pharmaceutical Analysis and Quality Assurance,
Nalanda College of pharmacy, Cherlapally, Nalgonda, Andhra Pradesh, India.
E-mail : som_subhra_ghosh@yahoo.co.in

ABSTRACT
The present research work discusses the development of UV Spectrophotometric method for the determination of Efavirenz  in bulk and pharmaceutical capsule dosage form. The present method is simple, rapid, accurate, precise and economical when compared to other methods. The absorption maxima of the drug were found to be 264nm for Efavirenz   in DMSO solvent system. The method is applied to capsule dosage form it gives best results of accuracy, precision & linearity over a range of 2-18µg/ml for Efavirenz. The percentage recovery was found to be 99.63- 101.48% for Efavirenz. Results were analysed and validated for various parameters as per ICH guidelines.
Key words: Efavirenz , Capsule dosage form, Method, Development, Validation.