Male Antifertility Activity of Hydro-Alcoholic Stem and Leaf Extracts of Ecballium Elaterium on Male Wistar Rats

¹Sarath Chandiran Irisappan, ²Jaya Kumar Annamalai*
¹Professor, Sun Institute of Pharmaceutical Education and Research, Nellore, A.P, India-524346
²Research Scholar, PRIST University, Thanjavur, Tamilnadu, India- 613403

A B S T R A C T
Objective: The objective was to investigate the male antifertility effect of hydro-alcoholic stem and leaf extracts of Ecballium elaterium on male Wistar rats. Methods: The animals were divided into five groups of five animals each. The first group (I) served as control and received normal saline remaining Groups (II, III, IV & V) were treated with plant extracts (HALEE & HASEE) at a dose of 200 & 400 mg/kg p.o. respectively for a period of 21 days. Results: Dose dependent significant decrease in the weight of testes & epididymis was observed. Also a dose related reduction in sperm count and motility was observed. Conclusion: In conclusion HASEE & HALEE extract of Ecballium elaterium has produced dose dependent antifertility effect o male rats.
Keywords: Male antifertility, Ecballium elaterium, testes, epididymis.