Kinetics of Rapid Chlorination of Imidazole by N-Chlorosuccinimide in Aqueous Medium and Study of Antimicrobial Activity of its Chloro Derivative

Sandhya B. Walke¹, Ranjana P. Bhadane¹, Sulabha B. Deokar², Shantaram L. Bonde*^1
1Department of Physical Chemistry, Nowrosjee Wadia College, Affiliated to Savitribai Phule Pune University, India
²Department of Biotechnology, Nowrosjee Wadia College, Affiliated to Savitribai Phule Pune University, India.

A B S T R A C T
The rapid kinetics of the chlorination of imidazole by N-chlorosuccinimide (NCS) has been studied using hydrodynamic voltammetry technique in aqueous medium. The specific reaction rate at the temperature 301.6 K is found to be 5.48M^-1s^-1. The mono chloro derivative formed in the reaction is confirmed stoichiometrically and by ¹H NMR spectral study. It was screened for antifungal and antibacterial activity against the different bacteria and fungi species by agar well diffusion method. The results of antibacterial and antifungal activity revel that the chloro derivative of imidazole acts as a potential antifungal and antibacterial agent.
Keywords: Kinetics, imidazole, hydrodynamic voltammetry, antimicrobial activity, agar well diffusion method.