Investigation of Tumor Markers Effect on Human Blood Plasma, Leukocyte and Erythrocyte Total Antioxidant Status

ABOUT AUTHOR 
*Nazan DEMİR, **Azize ALAYLI GUNGOR, *** Hayrunnisa NADAROGLU 
^*Mugla University, Science Faculty,  Chemistry Department, 48000, Mugla, Turkey
^**Ataturk University, Erzurum Vocational School, Department of Chemical Technology, 25240, Erzurum, Turkey
^***Ataturk University, Erzurum Vocational School, Department of Food Technology, 25240, Erzurum, Turkey

Abstract
Carcinoembryonic antigen (CEA) and (CA15-3), antigens that are sometimes found in an increased amount in the blood of people who have certain cancers, other diseases, or who smoke. In this study we aimed that clarified correlation amount of CEA and CA15-3 between total antioxidant status. For this aim, ABTS, chromogenic substrate was used to measure of variation of total antioxidant status. The resultant ABTS radical cation is blue-green in color, with the degree of suppression of color production being proportional to the antioxidant concentration (CEA and CA15-3) of the added sample. TAS% was decreased in the presence, tumor marker (CA15-3)of plasma and white blood cells 3.9×10^-3 kU/L and 15.6×10^-3 in erythrocyte kU/L. CAE exchange with the TAS in plasma was examined; the marker is increased in proportion to the concentration of TAS%. 1.6×10^-3 concentration of leukocytes TAS% had the lowest value. Obtaining data show that the amount increasing of total antioxidant status is parallel to the increasing amount of CEA and CA15-3.
Keywords: CA15-3 (Cancer Antigen 15-3), Carcinoembryonic Antigen (CEA), Total Antioxidant Status (TAS), Tumor marker.