Investigation of Nephroprotective Activity of Amaranthus Paniculatus Leaves in Rats

B. Harshini¹, Murali Sollu*², Dr. Gampa Vijay kumar^3
1,2,3KGR institute of Technology and Management, Rampally, Keesara, Rangareddy, Telangana, India

ABSTRACT
Nephrotoxicity is one of the most common kidney problems and occurs when body is exposed to a drug or toxin. A number of therapeutic agents can adversely affect the kidney resulting in acute renal failure, chronic interstitial nephritis and nephritic syndrome because increasing number of potent therapeutic drugs like amino glycoside antibiotics, chemotherapeutic agents and NSAIDS. The aim of the present work is to screen the nephroprotective activity of Amaranthus Paniculatus against Azathioprine induced oxidative stress in rats by decreasing the oxidative stress biomarkers serum creatinine and serum urea in kidneys. Amaranthus Paniculatus has antioxidant effect, elevated by measuring antioxidant enzymes. There is increase in superoxide dismutase in liver and kidney tissues in Azathioprine induced oxidative stress in rats. It has high scavenging activity against DPPH free radical generating system. Amaranthus Paniculatus has nephropretective effect against Azathioprine induced toxicity in kidneys by observing the histopathological changes in rat kidney tissues also has many pharmacological activities like analgesic, antiviral activities.
Keywords: Amaranthus Paniculatus, nephropretective.