Impact of rickettsial bacterial disease on immune system

Impact of rickettsial bacterial disease on immune system
Amit Gupta¹ and Sushama R Chaphalkar^{1, 2}*
¹Department of Immunology, Vidya Pratishthan’s School of Biotechnology (VSBT) Vidyanagari, Baramati, Pune, India
²Director, Vidya Pratishthan’s School of Biotechnology (VSBT) Vidyanagari, Baramati, Pune, India

A B S T R A C T
Rickettsia belonging to the family Rickettsiales. The number of human cell types which is targeted by rickettsia i.e. macrophages are the members of innate immunity which is capable of enhanced or inhibit the inflammatory responses. In this paper, we discuss about the rickettsia negative and positive blood samples of human and studied its various immunological parameters i.e. CD3/CD4/CD8 population and peritoneal macrophages activation in mice. These studies directly or indirectly correlate with the innate as well as adaptive immune system.
Keywords: Rickettsia, Rickettsiales, peritoneal macrophages