Highly Efficient Green Synthesis and Characterization of 6-Amino Flavonones by Microwave Irradiation and Their Possible Activities

Dr. Fouzia Tehseen^1*, Dr. Syed Safiullah Ghori², Saneela Sajid³, Bushra Fatima³, Naghma Fatima³, Nousheen Fatima³, Neha Samreen³, Abu Baker^3
1Department of Pharmaceutical Chemistry, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana.
²Department of Pharmacology, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana, India.
³Students, Anwarul Uloom College of Pharmacy, Hyderabad, Telangana, India.

A B S T R A C T
In today’s world of competitive research it is necessary to develop newer and greener methodologies  in the field of organic synthesis. Microwave serves as an efficient tool in research studies which makes the reactions cheap, solvent free, and economic in terms of time and energy. Flavonoids are explored and have potential anti-cancer, anti-tubercular, anti-malarial, anti –inflammatory, Antioxidant, anti-infective, antiviral activities etc., because of the prescence of the chromone pharmacophore. We have developed a four steps new methodology for the synthesis of 6-amino flavanones. We started with paracetamol which was acetylated and then condensed with an aldehyde to give chalcone. Further it was converted to 6 acetamino flavanone. The acetamino group was converted to amino group to give 6 amino flavanones.
Keywords: green methodology, microwave assisted synthesis, flavonoids, amino flavanones.