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Dr. K Jithender*, Anumakonda Rishika¹, Carol Biju Philips¹, Maseerah Siddiqua¹, Dr. Chandra Sekhar Dannana2, Dr. Saritha Jyostna Tangeda3, Dr. Venu Talla4, Divya Sreemantula5, Dr. Aakaram Sujala6
*Assistant Professor, Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Tarnaka, Hyderabad, Telangana, India, 500017.
1Pharm.D V Year, Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Tarnaka, Hyderabad, Telangana, India, 500017.
2Sr. Consultant Orthopedic Surgeon, Medicover Hospitals, Madhapur, Hyderabad, Telangana, India-500081.
3Principal,Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Tarnaka, Hyderabad, Telangana, India, 500017.
4Professor & HOD, Department of Pharm.D, Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Tarnaka, Hyderabad, Telangana, India-500017
5Assistant Professor, Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Tarnaka, Hyderabad, Telangana, India-500017
6Assistant Professor, Department of Pharm.D, Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Tarnaka, Hyderabad, Telangana, India-500017
Int. J. Pharm. Natural Med., 2024, 12(1): 01-06.
DOI: https://doi.org/10.30904/j.ijpnm.2024.4628
A B S T R A C T
Osteoarthritis is the second most common inflammatory arthropathy with a prevalence of 22% to 39% in India. Osteoarthritis (OA), also known as a degenerative joint illness, is a chronic, painful, and inflammatory disease that affects the joints. It is characterized by chronic joint pain, stiffness, inflexibility, swelling, narrowing of joint spaces, and formation of osteophytes. The most common medications include anti-inflammatory drugs, analgesics, weak opioids, and corticosteroids. These agents are inadequate to effectively reduce the pain or reverse the OA symptoms. Nutraceuticals are also used to ease their pain and discomfort. It can be used as an alternative therapy to avoid the negative effects of taking NSAIDs. These are considerably safe and well tolerated. Participants who met the study’s eligibility requirements were enrolled and given instructions to report for a baseline evaluation. At the first treatment visit (Visit 2), selected subjects were randomly assigned and treated with UC-Il or Glucosamine. On each visit day (day 30, 60, 90), subjects were followed up for medical and physical examination. The pain score assessments included WOMAC, VAS and Oxfordknee pain scores. Each patient participated in the trial by keeping a subject treatment diary that recorded side events, medication use, and product compliance. Out of 100 patients included in the study, 91 patients have completed 3 months of nutraceutical therapy for mild to moderate management of OA. Among 91 patients, 63 patients were prescribed with UC II Collagen and 28 patients were prescribed with Glucosamine supplement. The patients were analysed for improvement in symptoms by using 3 standard questionnaires to assess the outcomes. Patient follow up was done to collect data and results were statistically analyzed. It was observed that both the supplements had efficacy in improvement of symptoms of OA i.e., pain, stiffness and physical function difficulties. Upon comparison of efficacy of UC II Collagen vs Glucosamine, it revealed that there is no statistical significant difference between their outcomes. The study demonstrates that upon administration of nutraceutical i.e., UC II Collagen or Glucosamine, for a period of 3 months have significantly shown to improve symptoms of Knee OA. Use of such supplements has resulted in fewer use of analgesics. Both Undenatured Type II Collagen and Glucosamine display equivalent efficacy and yield functional outcomes among patients afflicted with Grade 2 and Grade 3 OA in the knee joints, and found to improve QoL.
Keywords: Medicover Hospital, QoL, arthropathy, OA symptoms, WOMAC, VAS and Oxford
