Formulation and Evaluation of Simvastatin Nanosponges by Emulsion Solvent Diffusion Method

S. Bhuvaneswari^a*, S. Sanjeeva kumar^a, P. Preethi^a, B. Joseph^a, V. Viswanath, B. Narasimha Rao, S. Rahath fathima, B. Syed Salman
^a*Department of Pharmaceutics, P. Rami reddy memorial college of pharmacy, Kadapa, Andhra Pradesh, India-516003

A B S T R A C T
Targeted drug delivery system is based on a method that delivers a certain amount of a therapeutic agent for a prolonged period of time to a targeted diseased area within the body. The purpose of present study  was to formulate nanosponges of simvastatin having bioavailability of 5% with half life 2hours and protein binding 95%.Nanosponges are targeted drug delivery systems applicable to solve the bioavailability problems by releasing the drug at specific target site. In this study, nanosponges are prepared by emulsion solvent diffusion method using different ratios of ethyl cellulose and Polly vinyl alcohol. The elevated characteristics can be estimated Particle size analysis and surface morphology of nanosponges were performed. The scanning electron microscopy of nanosponges showed that they were spherical in shape and spongy in nature. The particle size of the optimized formulations was in the range of 200-400nm and the drug entrapment efficiency was found to be in the range of 85.6 % to 90.8%. Among all the formulations prepared F1 were found to show the maximum drug release of 76.04%.
Keywords: Nanosponges, simvastatin, hyper cholesteremia, targeted drug delivery system, emulsion solvent diffusion method.