Formulation and Evaluation of Atenolol floating Drug Delivery Systems

Tharun D*, N. Devanna, Thirumalesh Naik SB, Siva Kumari K, Hindustan Abdul Ahad, Maddileti R
Jawaharlal Nehru Technological University Ananthapur, Oil Technological and Pharmaceutical Research Institute, Ananthapuramu, Andhra Pradesh, India -515001

ABSTRACT
Gastro retentive drug delivery is apracticeto extend stomach retaining and aiming stomach site for local or systemic effects. Atenolol is a cardio selective β₁ blocker used in the treatment of angina pectoris and hypertension, which has a biological half-life of 6 h with a dose of 50-100 mg daily. It is considered as an ideal drug for designing of gastro retentive floating drug delivery system because of its poor absorption. The use of HPMC, Carbopol 934P, polymer matrices has become extremely popular in controlling the release rate of drugs from solid dosage forms. Effervescent floating tablets of Atenolol was prepared by direct compression method using different hydrophilic polymers and tablets were evaluated for hardness, friability, weight variation, drug content uniformity, swelling index, in-vitro floating studies, drug-polymer interaction and in-vitro drug release. Based on the experimental results the formulated tablets show non-fickian diffusion and controlled zero order kinetic. Formulation (F-7) showed the better drug release for a period of 12 h dissolution in 0.1N HCl.
Keywords: Atenolol, HPMC, FDDS, Gastro retentive, buoyant.