Formulation development and in-vitro evaluation of controlled release dalfampridine hydrogel beads

Maddala Anitha*, Bhogireddi Sriswetha, D. Raghava, K. Nageswara Rao
Department of Pharmaceutical Technology, K.G.R.L College of Pharmacy, Bhimavaram-534201, Andhra Pradesh, India

A B S T R A C T
The concept of formulating hydrogel beads containing Dalfampridine offers a suitable, practical approach to achieve a prolonged therapeutic effect by continuously releasing the medication over extended period of time. In present work, hydrogel beads of Dalfampridine were prepared successfully by ionotropic gelation method using different polymers. Formulated beads were evaluated for SEM, Percentage Drug content & In-vitro dissolution studies. Pre-formulation studies like melting point, solubility and UV analysis complied with standards. The FT-IR Spectra revealed that, there was no interaction between Dalfampridine and polymers. Surface smoothness of the Dalfampridine beads was confirmed by SEM. As the ratio of polymer was increased, the mean particle size of Dalfampridine floating beads was decreased. Dalfampridine floating beads with normal frequency distribution were obtained. From in-vitro dissolution studies, F3 formulation containing Carbopol 940 shows prolonged and controlled release up to 20 hrs. Which follows zero order release with super case transport mechanism.
Keywords: Dalfampridine, HPMC K100M, HPMC K30M, Carbopol 940, controlled release