Formulation Development and Characterization of Rosuvastatin Inclusion Complexation

Saravanakumar K*, Sree Nagavalli K, Fayaz S, Vedhapriya C, Reshma S, Amulya J
Department of Pharmaceutics, Sree Vidyanikethan College of Pharmacy, A.Rangampet, Tirupati-517102, Chittoor District, Andhra Pradesh, India.

A B S T R A C T
The present investigation is to study the influence of β-Cyclodextrin and hydroxy propyl β-Cyclodextrin on 1:1, 1:2 molar ratios of Rosuvastatin inclusion complexations which are prepared by using various methods such as co-grinding, kneading method. Drug and excipient compatability studies like solubility, chemical interaction studies were performed for individual and combined forms. From the preformuation studies, it was found that individual and combined forms were compatible by the conduction of FTIR study. The prepared formulations were subjected for production yield, drug content, and in-vitro drug release. The cumulative percent drug release for the optimized formulation K2 showed 40.11% at the end of the 120 minutes. Hydroxy propyl β-Cyclodextrin had showed excellent dissolution profile of Rosuvastatin when compared to β-Cyclodextrin inclusion complexation.
Keywords: Absorption, Amorphous, Crystalline, Solubility, Mass transfer.