Formulation and In-Vitro Evaluation of Terbutaline Sulphate Sublingual Tablets

¹T Anusha, ²GS. Valluri, ³Kishore Kamere, ⁴Vijay Kumar Gampa
^1,2,3,4 Department of Pharmacy, KGR Institute of Technology and Management, Rampally, Keesara, Medchal–501301, Telangana, India.

A B S T R A C T
In the present work, an attempt has been made to develop Sublingual tablets of Terbutaline sulfate. Chitosan, Cross povidone and Croscarmellose sodium were employed as super disintegrating agents to enhance the solubility and dissolution rate of selected drug molecule. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F2 formulation showed maximum % drug release i.e., 98.36 % in 8 min hence it is considered as optimized formulation. The F2 formulation contains chitosan as super disintegrate in the concentration of 10 mg.
Keywords: Terbutaline sulfate, Chitosan, Cross povidone, Croscarmellose, Sublingual tablets