Formulation and In-Vitro Evaluation of Glibenclamide Floating Microspheres

A B S T R A C T
The aim of present work is prepare floating microspheres of Glibenclamide using Eudragit S 100 and Eudragit L 100 as polymer. Floating drug delivery system have a bulk density less than gastric fluids and so remains buoyant in the stomach without affecting gastric emptying rate for aprolonged period of time. Glibenclamide is antidiabetic drug with long elimination half life 8-10 hours. The long half life of Glibenclamide and multiple administration doses make Glibenclamide a very good candidate for formulation of floating drug delivery system. Floating microspheres of Glibenclamide were prepared by emulsion solvent diffusion method using Eudragit S 100 and Eudragit L 100 as polymer. The floating microspheres was evaluated such as micromeritic properties, particle size, percentage yield, In vitro buoyancy, incorporation efficiency, drug polymer compatibility (IR & DSC study), scanning electron microscopy and drug release of microspheres. The micromeritic properties was found to be good and scanning electron microscopy confirmed their hollow structure with smooth surface. Formulation GFM2 prepared with Eudragit S 100 drug: polymer ratio (1:2) which exhibited excellent micromeritic properties, percentage yield, In vitro buoyancy, incorporation efficiency and percentage drug release 92.26 % for a period of 12 hrs. Results show that as increase in drug: polymer ratio affects the particle size, percentage yield, In vitro buoyancy and drug release of microspheres. The data obtained in this study thus suggest that a floating microspheres of Glibenclamide are promising for sustained drug delivery which can reduce dosing frequency.
Keywords: Glibenclamide, Eudragit S 100, Eudragit L 100, Floating microspheres.