Formulation and In-Vitro Evaluation of Ganciclovir Liposome

Kethavath Kumar¹, Dr. V. Anjaneyulu², Dr. G. Vijay Kumar^3
1,2,3KGR Institute of Technology And Management, Rampally, Keesara, Medchal-Malkajgiri, Telangana, India.

A  B  S  T  R A C T
Ganciclovir, is an antiviral medication used to treat cytomegalovirus (CMV) infections. In the present work an attempt was being made to formulate and evaluate ganciclovir liposomes. Phosphatidylcholine, Cholesterol, Methanol and Chloroform were used as excipients in the preparation of liposomes. The drug and excipient compatibility was studied by using FTIR. Prepared liposomes of ganciclovir were incorporated into a gel using Carbopol 934. The developed formulation was evaluated for drug entrapment efficiency, pH measurement, in vitro drug release, drug content. F8 formulation shown maximum drug release which is considered as the optimized formulation.
Keywords: Ganciclovir, Liposomes, Phosphatidylcholine, Cholesterol.