Formulation and In-Vitro Evaluation of Colon Targetted Drug Delivery System of Olsalazine Tablets

M. Lalitha¹, B. Rajam*², B. Heeralal^3
1Mother Teresa College of Pharmacy, NFC Nagar, Ghatkesar, Hyderabad, Telanagana.
²Assistant Professor, University College of Technology, Osmania University, Hyderabad, Telangana.
³Research Scholar, Department of Pharmacy, University College of Technology, Osmania University, Hyderabad, India. 

A B S T R A C T
In the present research work colon formulation of Olsalazine targeted to colon by using various polymers developed. To achieve pH-independent drug release of Olsalazine, pH modifying agents (buffering agents) were used. Colon targeted tablets were prepared in two steps. Initially core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethyl cellulose, Eudragit RLPO and S100 were used as enteric coating polymers. The precompression blend of all formulations was subjected to various flow property tests and all the formulations were passed the tests. The tablets were coated by using polymers and the coated tablets were subjected to various evaluation techniques. The tablets were passed all the tests. Among all the formulations F6 formulation was found to be optimized as it was retarded the drug release up to 18 hours and showed maximum of 98.45% drug release. It followed first order kinetics mechanism.
Keywords: Olsalazine, Colon targeted drug delivery system, Ethyl cellulose, Eudragit RLPO, Eudragit S100