Formulation and In-vitro Evaluation of Colon Targeted Drug Delivery of Dicyclomine Tablets

D. Keerthi Raj*, B. Ramya Sree, S. Anusha, T. Anil Goud
Assistant Professor, Department of Pharmaceutics, Vijay College of Pharmacy, Nizamabad, Telangana, India

A B S T R A C T
In the present research work sustained release matrix formulation of Dicyclomine targeted to colon by using various polymers developed. Initially core tablets were prepared and then the tablets were coated by using different pH dependent polymers. Ethyl cellulose, Eudragit L100 and S100 were used as enteric coating polymers. The precompression blend of all formulations was subjected to various flow property tests and all the formulations were passed the tests. The tablets were coated by using polymers and the coated tablets were subjected to various evaluation techniques. The tablets were passed all the tests. Among all the formulations F3 formulation was found to be optimized as it was retarded the drug release up to 18 hours and showed maximum of 98.09% drug release.
Keywords: Dicyclomine, colon, Ethyl cellulose, Eudragit L100 and S100