Formulation and In-vitro Characterization of Repaglinide Floating Microspheres

Gundu Sunitha¹, V. Kiran Kumar², Y. Ganesh Kumar^3
1Unity College of Pharmacy, Raigiri, Bhongir, Yadadri Bhongir, Telangana, India.
²Princpal & Professor, Unity College of Pharmacy, Raigiri, Bhongir, Yadadri Bhongir, Telangana, India.
³Associate Professor & HOD, Department of Pharmaceutics, Unity College Of Pharmacy, Raigiri, Bhongir, Yadadri Bhongir, Telangana, India

A B S T R A C T
In the present work, floating microspheres of Repaglinide using HPMCK100M, HPMCK15M, HPMC K4M as copolymers were formulated to deliver Repaglinide via oral route. The results of this investigation indicate that ionic cross linking technique Ionotropic gelation method can be successfully employed to fabricate Repaglinide microspheres. The technique provides characteristic advantage overconventional microsphere method, which involves an all-aqueous system, avoids residual solvents in microspheres. Other method sutilize larger volume of organic solvents, which are costly and hazardous because of the possible explosion, air pollution, toxicity and difficult to remove traces of organic solvent completely. Micromeritic studies revealed that the mean particle size of the prepared microspheres was in the size range of 512-903µm and are suitable for bioadhesive microspheres for oral administration. Increase in the polymer concentration led to increase in% Yield,% Drug entrapment efficiency, Particle size, % swelling and % Mucoadhesion. The in-vitro mucoadhesive study demonstrated that microspheres of Repaglinide using albumin along with HPMCK100M as co polymer adhered to the mucus to a greater extent than the microspheres of Repaglinide using albumin along with HPMCK15M and HPMC K4M as copolymers.
Keywords: Repaglinide, HPMC, Microspheres