Formulation and Evaluation of Repaglinide Insitugel

G. Uma Rani^1*, R. Nagaraju^2
1RBVRR Women’s college of pharmacy, Hyderabad.
²Institiute of Pharmaceutical technology, Sri padmavathi mahila university, Tirupathi.

A B S T R A C T
The  present  research  was  focused  to  develop  the  formulation  to  release  the  drug Repaglinide for an extended period of time and buoyant, thus prolong the residence time of formulation in the stomach. Sodium alginat, Chitosan, Carbopol934P are used as polymers. sodium citrate and calcium carbonate are the main ingredients for the formation of gelling solution. In the present study calcium ions released from calcium carbonate complexes with citrate ions. The conversion of complexed calcium into free calcium causes gelation of Alginate. In order to release the drug from the formulation the gelled material floats upwards with a potential in the stomach. Based on the concentration of polymer the drug release was varied. Totally 18 formulations were prepared with sodium alginate, Chitosan and Caropol 934P in  various combinations. Invitro evaluation study was conducted in USP- Type II apparatus. In all the formulations,MIG-4 and MIG-9 are optimized for 8 hrs. The viscosities of the samples were measured by Brookfield Viscometer. The porosity of gel was evaluated by using scanning electron microscope. The floating in-situ gels can be formulated by using polymers like Chitosan, Carbopol 934P  and natural polymers like Xanthu Gum.This formulation enhances the residencetime. The in-situ gel formulations were developed for improve patient complence.
Keywords: Formulations,MIG-4 and MIG-9, Chitosan, Carbopol 934P