Formulation and Evaluation of Niosomes of Valacyclovir Hydrochloride

A. Ankarao, CH. Sowjanya*, Dr.A. Seetha Devi, V. Vasu Naik, A. Rajesh
Department of Pharmaceutics, Hindu College of Pharmacy, Amaravathi Road, Guntur

A B S T R A C T
Valacyclovir hydrochloride niosomes were prepared by thin film hydration and ether injection process with different ratios of (1:2:2, 1:4:2) drug and and Span-80 ,span 20(Non-ionic surfactant) cholesterol. The niosomes prepared were in the size range of 0.5-5 microns in the case of hand shaking process and 0.5-2.5 microns in the case of Ether injection process. The order of encapsulation efficiency increases when span-80 concentration was increased. In-vitro release study on valacyclovir hydrochloride niosomes indicates 99.15% release for formulation prepared with cholesterol: Span-80 (2:4) and it takes an extended period of 1 day and 12 h for release.
Keywords: Gene, RAPD, antioxidants, antibacterial activity, Solanum nigrum, Fusarium.