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Surya Akhil Raj1, G Mahaboob Basha*2
1M. Pharm Student, Department of Pharmaceutics, Prabhath Institute of Pharmacy, Parnapally (Vil.), Bandiatmakur (MD), Nandyal Dist., Andhra Pradesh
2Associate Professor, Department of Pharmaceutics, Prabhath Institute of Pharmacy, Parnapally (Vil.), Bandiatmakur (MD), Nandyal Dist., Andhra Pradesh
A B S T R A C T
Encapsulation of medicaments in vesicular organization can be expected to prolong the availability of the medicaments in the systemic circulation and hence augment penetration into objective tissue and diminish toxicity. Proniosome formulations are minute lamellar arrangements of alkyl or dialkyl polyglycerolnon-ionic surfactant, cholesterol and hydrophilic carrier molecule. On hydrolysis they generate unilamellar or multi-lamellar noisome vesicles that leads to better drug delivery. Proniosomes enter in the human body, they are recognized as the foreign bodies and easily taken up by the mononuclear phagocytic cells. HIV is present in mononuclear phagocytic cells of infected patient, so proniosomes represent suitable carriers for targeting anti-HIV drugs to the infected cells. The present study was undertaken to formulate pronoisome carrier system for antiviral drug Lamivudine by slurry method using commonly available surfactants like span 20, span 40, span 60, span 80, tween 20, tween 40, tween 60 and tween 80. A total of 16 formulations were prepared to achieve the encapsulation of Lamivudine in vesicular carrier system.The mean vesicle size of proniosome derived vesicles in case of charge inducer incorporated formulations were in the range of 131.8 ±8.45 to 178.8 ±6.87 respectively. In case of the formulations without charge inducer the size of drug loaded formulations were in the range of 129.1±15.808 to 176.2±9.735 respectively.Zeta potential of the proniosomal formulations were found in range of -33.0 ±1.17 to -44.3 ±1.74 for charge inducer and -2.23±0.521 to 32.5±0.833 in the formulations without charge inducer.
Keywords: Lamivudine, Niosomes, Proniosomes, Surfactants, Charge inducer etc
