Formulation and Evaluation of Lamotrigine Mouth Dissolving Tablets

Dr. B. Venkateswara Reddy¹*, K.V. Ramana Reddy², Ayesha Sultana^1
1Department of Pharmaceutics, St.Paul’s College of Pharmacy, Turkayamjal (V), Hayathnagar (M), R.R.Dist-501510, India.
²Sree Datta Institute of Pharmacy, Sheriguda (v), Ranga Reddy Dist-501510, India

A B S T R A C T
In the present work an attempt has been made to develop fast disintegrating tablets of Lamotrigine. New generation super disintegrants Solutab, Explotab and Polyplasdone XL was selected. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets have shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F4 formulation showed maximum % drug release i.e., 100.4 % in 10 min hence it is considered as optimized formulation. The F4 formulation contains Solutab as superdisintegrant in the concentration of 20 mg.
Keywords: Bore wells drinking water, Dissolved salt, TDS, Kathlal tehasil.