Formulation and Evaluation of Gastroretentive Floating Tablets of Sumatriptan Succinate

Dr. R. Srinivasan¹, Sk. Shakir Ahmad¹*, D. SK. Sarma¹, D. Rajesh Kumar¹, Dr. K. Ravi Kumar², V. Mahesh Swami^1
1Siddhartha Institute of Pharmaceutical Sciences, Jonnalagadda, Narsaraopet, Guntur, A.P, India
²Assosciate Professor, Hindu college of Pharmacy, Guntur, Andhra Pradesh, India

A B S T R A C T
The purpose of present investigation was to develop and evaluate floating drug delivery system of an antimigraine drug (sumatriptan), the floating tablets of Sumatriptan were prepared by using HPMC K15M, HPMCE15LV, Carbopol 940 polymers. The precompression and post compression evaluation were performed as per pharmacopoeial standards. The tablets were prepared by direct compression method. Dissolution measurements were carried out in a (USP) dissolution testing apparatus II. Compatibility study was performed by FTIR. The compatibility study of the prepared Sumatriptan floating tablets confirms that there is no interaction between the drug and polymers used. The release data were subjected to different models in order to evaluate their release kinetics and mechanisms. The drug release kinetics was observed by Non- fickian diffusion mechanism. The floating lag time were found to be significantly increased with the increasing concentration of the polymers. After the dissolution study of prepared Sumatriptan floating  tablet  it  was  concluded  that  the  formulation  with HPMC E15 LV shows better sustained release effect. The release kinetic data implies that the release mechanism of all the formulations was Non-fickian. The developed floating tablets of Sumatriptan may be used to prolong drug release for at least 12h, thereby improving the bioavaibility and patient compliance.
Keywords: Sumatriptan, gastroretentive, floating drug delivery, sustained release.