Formulation and Evaluation of Fast Dissolving Oral thin film of Ropinirole HCl

About author
Swapnil D. Salunkhe*, Bhushankumar S. Sathe, Parag Jain, Ravindra N. Patil
Department of Pharmaceutics,
Smt.S.S.Patil College of Pharmacy,Chopda

Abstract
The present work aimed at preparing fast dissolving oral thin films of Ropinirole Hydrochloride with the purpose of developing a dosage form for a very quick onset of action, which is very convenient for administration, without the problem of swallowing and using water. The film of Ropinirole Hydrochloride was prepared by using polymers such as polyethylene oxide and glycerine as plasticizer, by a solvent casting method. The formulated fast dissolving films were evaluated for physical characteristics such as uniformity of weight, thickness, folding endurance, drug content uniformity, surface pH and percentage elongation, tensile strength using texture analyser. The formulations were subjected to disintegration, In-vitro drug release tests. The FTIR and DSC studies revealed that no physicochemical interaction between excipients and drug.  Fast dissolving film of Ropinirole Hydrochloride containing polyethylene oxide as polymer showed (99.18± 0.78%) drug release at 60 sec. Percentage content uniformity (99.90± 1.25%). Fast dissolving films of Ropinirole Hydrochloride can be considered suitable for clinical use in the treatment of parkinson’s disease and rest leg syndrome, where a quicker onset of action for a dosage form is desirable along with the convenience of administration.                                                                              
Key word: Ropinirole Hydrochloride, Polyethylene oxide, Solvent Casting method,  Texture analyser, Atomic force Microscopy, XRD, and SEM (scanning electron microscopy).