Formulation and Evaluation of Fast dissolving film coated tablets of Zopiclone

B. Ranganayakulu*, R. Lingaswami naik¹, Dr. S. Mohammed Yusuf², Dr.A.Srikanth^3
*,2Associate Professor, Srinivasa Institute of Pharmaceutical Sciences, Proddatur, A.P, India
¹Srinivasa Institute of Pharmaceutical Sciences, Proddatur, A.P. India
³Assistant Professor, Vasavi Institute of Pharmaceutical Sciences, Kadapa, A.P. India

A B S T R A C T
The objective of the present investigation was to formulate and evaluate fast dissolving film coated tablets of Zopiclone by solvent casting technique. Zopiclone is a non-benzodiazepine hypnotic agent, with marked sedative effects. Nine formulations of fast dissolving tablets were prepared using solvent casting method various polymers like PVA, Maltodextrins, HPMC 5cps and HPMC 6cps were used to prepare the FDFs of Zopiclone. Plasticizer (glycerin) at 150 mg concentration of total polymer weight gave excellent results in preliminary work. The evaluation results revealed that all formulations comply with the specification of official pharmacopoeias and/or standard reference with respect to general appearance, content uniformity, hardness, friability and dissolution. Out of all the formulation developed, Formulation 3 has been found that HPMC 6cps with 400 mg gave good results as compared to PVA and HPMC5cpsm and Maltodextrin. Different concentrations of the glycerin (90,120and 150 mg of dry polymer weight) were used as a plasticizer during film formation. Hence, developed fast dissolving film formulation can be a new era of drug delivery in future.
Keywords: Zopiclone, Solvent casting technique, Polymers, Formulation, HPMC5cpsm and Maltodextrin.