Formulation and Evaluation of Carvedilol Oral Disintegrating Tablets

M. Lokeswar Reddy*, P. Anil Kumar Reddy, D. Chinababu
Prabhath Institute of Pharmacy, Nanadyal, Kurnool, India

A B S T R A C T
The oral medication is easy to manufacture, compact, and convenient for self-administration, it is regarded as the most frequently approved method of administration. Due to their substantial influence on patient compliance, oral disintegrating tablets (ODT) have become more popular. New ODT technologies enable high drug loading, palatable taste, pleasant mouth feel, and minimal mouth residue following oral administration. ODT have been investigated for their potential in improving bioavailability of poorly soluble drug through enhancing the dissolution profile of the drug and hepatic metabolism drugs. The goal of the current study was to design and assess carvedilol fast-dissolving tablets for the efficient treatment of angina pectoris, hypertension, and other conditions. Considering its shorter plasma half-life and significant first pass effect. This study was attempted to create and assessed Carvedilol oral disintegration tablets using the direct compression method by using a variety of super disintegrants like cross povidone (XL-PVP), Croscarmellose sodium (Ac-Di-Sol®) sodium starch glycolate along with other excipients and 9 formulations were prepared. The formulations were subjected for both the evaluation of pre and post formulation studies. DSC and IR spectroscopy data shown the characterization of drug, excipient, compatibility of drug and solid dispersion with excipients, gave evidence of solid dispersion formation and UV absorption spectra shown enhancement of solubility. Various preformulation batches (F1- F9) formulated by direct compression method using different concentrations of polymers. After a number of evaluation processes, it was found that F9 formulation met all requirements for the fast oral disintegration tablets by using Carvedilol with cross povidone and drug release was found to be 98.97%.
Keywords: Carvedilol, Disintegration, Cross Povidone, Sodium Starch Glycolate.