Formulation and Evaluation of Abacavir Sulphate Sustained Release Tablets

Anand Babu U*, Hindustan Abdul Ahad, Sreedhar V, Bala Chandu M
PG Department of pharmaceutics, Balaji College of pharmacy, Ananthapuramu, Andhra Pradesh, India
APOTHEKE-2014, 8 Nov 2014, Organized by Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India

Abstract
The main objective of the present study was to formulate once a daily dose of Abacavir Sulphate sustained release tablets by direct compression technique.. The polymers used to sustain the drug release are Guar Gum, Xanthum Gum, Eudragit L100. The compatibility studies between the drug and the polymer were studied using the FTIR spectroscopy and were found to be compatible. Preformulation parameters like, tapped density, bulk density, carr’s index, Hausner’s ratio, compressibility index, angle of repose are studied and the results were found to be within the limits. Using the above polymers formulations F1 to F9 were manufactured by direct compression technique and the tablets were evaluated for their thickness, hardness, friability, weight variation and content uniformity test.
Keywords: Abacavir Sulphate, tablets, Direct compression, Guar Gum, Xanthum Gum, Eudragit L100