Formulation and Comarative Evaluation of Amlodipine Besylate Fast Disintegrating Tabltes Prepared by Dry and Wet Granulation Techniques

B.V. Ramana¹*, T.E.G.K. Murthy^2
1Research Scholar, Rayalaseema University, Kurnool, Andhra Pradesh, India
²Bapatla College of Pharmacy, Bapalta, Guntur Dist, A.P, India

A B S T R A C T
An Attempt was made to improve the disintegration capacity and Dissolution efficiency of the prepared formulations with the use of mixture of superdisintegrants. Amlodipine Besylate prepared alone with super disintegrates has shown the less release profile when compared to the release profile shown by the formulations with mixture of super disintegrates. The work proved that though wet granulation technique is best suitable technique for the preparation of tablets, the tablets prepared by direct compression improved the rate of dissolution quietly which favored the objective of improved solubility and faster absorption. The basic approach followed by all the currently available technologies engaged in the formulation of Fast dissolving tablets is to maximize the porous structure of the tablet matrix and incorporate super disintegrating agents in optimum concentration so as to achieve rapid disintegration and instantaneous dissolution of the tablet along with good taste masking properties and excellent mechanical strength has been achieved. The availability of the various technologies and manifold advantages of Fast dissolving tablets will surely increase its popularity in the near future.
Keywords: Amlodipine besylate, Direct Compression, Wet Granulation, Disintegration