Fabrication of Lansoprazole sustained Release Matrix Tablets: In vitro evaluation

Vani N, Hindustan Abdul Ahad, Prathima G, Manuja T, Amani P
Balaji College of Pharmacy, Ananthapuramu, Andhra Pradesh, India

A B S T R A C T
The main objective of the present study was to develop matrix tablets of Lansoprazole and to study its sustained release for prolonged time in tablet formulations. Compatibility of Lansoprazole with excipients used was verified by DSC and FTIR studies. The prepared tablets were found to have better uniformity of weight and drug content with low SD values. The swelling behavior and release rate characteristics were studied and found good. The dissolution study proved that the Lansoprazole released from the dosage form in sustained manner for prolonged time.
Keywords: Lansoprazole, matrix, tablets, sustained release.